2023 Volume 57 Issue 1 Pages 131-136
We investigated the effect of blue light-emitting diode (LED) irradiation on the cariogenic bacteria Streptococcus mutans (S. mutans) and the gingival epithelial cell line GE-1 cells. Light-emitting diodes with a wavelength of 465 ± 10 nm were used to irradiate the S. mutans and GE-1 cells, and the cell viability was measured. The induction of the antioxidant enzyme heme oxygenase-1 was evaluated using quantitative reverse transcription polymerase chain reaction and western blotting. The results showed that blue LED irradiation with vitamin B partly suppressed the growth of S. mutans, and induced reactive oxygen species in GE-1 cells, thereby reducing cell viability. (J Osaka Dent Univ 2023; 57: 131-136)
