Abstract
Using an experimental apparatus for estimating neurotransmitter release from brain slices, which involved an improved type of perfusion chamber and more well-controlled tube lines than the previous one were aspartic acid and γ-aminobutyric acid (GABA) release from hippocampal slices from epileptic El mice estimated more exactly and stably. Zonisamide had no effect on the aspartic acid release from hippocampal slices of El mice by zonisamide. However, zonisamide accelerated dose dependently GABA release from hippocampal slices of non-stimulated El mice, though no such acceleration was observed in stimulated El mice, i.e., repeatedly convulsed El mice.
