Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
Online ISSN : 1882-4528
Print ISSN : 0030-1558
NEOPLASTIC CHANGES DEVELOPING IN HUMAN AMNION CELL LINE DERIVED FROM NORMAL PERSON
Eiji HamamotoIsamu KitamuraMikio MyojyoKiyofumi TuguKeizo TanigawaTakuzo OdaIwao Matuoka
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1958 Volume 70 Issue 12supplement Pages A137-A142

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Abstract
Transplantability of successively cultivated human amnion cell to conditioned rats was demonstrated.
1) Fifty passaged human amniotic cell (Strain H) which derived from normal person had produced the tumor in the X-radiated and cortisone-treated rats, just as HeLa cell.
2) Transfer of the first generation of H rat tumor to the second generation of conditioned rats was successfuly done.
3) Regrown of H-rat and HeLa-rat tumor cell in tissue culture was carried out and subcultivation of these regrown cell line was now in progress. (H-R cell and HL-R cell).
4) Immunocytotoxicity of anti-H and HeLa-rabbit sera on the H-R cell and HL-R cell in vitro was demonstrated.
5) Malignancy of H cell was discussed.
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