Abstract
The author had an attempt to study the influence of splenectomy on the growth of Brown-Pearce Tumor by implanting its homogenate into the testicles of splenectomized rabbits. Not only transplantability, regression, days of survival and the mode of intraabdimonal metastasis but also the fluctuation in serum protein level, serum albumin globulin ratio, serum α1, α2 globulin fraction level and serum mucoprotein level in every 5 day after transplantation were examined.
1) Splenectomy has little influence on the transplantability and the regression of tumor in taken.
2) Mean days of survival were 16.2 in group transplanted with tumor within 3 weeks after splenectomy and 21.8 in nonsplenectomized group. But almost no differences in surviving time between the group transplanted with tumor 4 weeks or more after splenectomy and nosplenectomized group were seen.
3) On the mode of intraabdominal metastasis, the disseminated type with haemorrhagic ascites became to appear more frequently than the nodulated type without ascites in splenectomized group.
4) The decrease in serum protein level and serum albumin·globulin ratio after transplantation occurred early and intensively in splenectomized group.
5) In splenectomized group, it was very significant that the increase in serum α1 globulin fraction level, determined paper electrophoretically, which continued to increase until the tumor growth reached to its peak, was more intensive and that the fluctuation of its level preceded about 5 days.
6) The fluctuation of serum α2 globulin fraction level, also determined paper electrophoretically, was not so constant as that of α1, but about 5 days' precedence of it in splenectomized group was more or less observed, too.
7) Serum mucoprotein level was determined by Weimer-Moshin's method, and was found that it became higher gradully according as tumor grows. In splenectomied group, the maximal increase in the level appeared about 5 days earlier than in the level of control group.
From the results described above, the author presumed that the growth of Brown-Pearce Tumor would be accelerated by the splenectomy.
