Abstract
About 203 cases of simple diffuse goiter in the recent two years was measured with I131 for their iodine metabolism.
They were classified by their tissue pictures and the relation between the tissue pictures and iodine metabolism was studied.
Simple diffuse gioter is classified by its uptake curve into two types:
1. One which continues to ascend 24 hours.
2. One which reaches to its maximum uptake at 1-6 hours.
The first type was found in 78 cases. Generally speaking, in these cases, the biological half life of I131 in the thyroid is shorter than in normal man but longer than in the second type. No discharge of I131 after the administration of thiocyanate is found. Also failure to convert into an organic form is not found either by I131conversion ratio in the thyroid nor by analysis of labeled iodine in the thyroid with paper chromatograph. In T. S. H.-test, the uptake ratio shows no change but many of them shows the ascending of P. B. I.
The second type was found in 125 cases. The biological half-life of I131 is shorter than the first type. Examination using thiocyanate and analysis of labeled iodine in the thyriod shows a distinct organic failure. In T. S. H.-test many of them shows no ascending in uptake curve and P. B. I.
Desiccate thyroid mostly does not effect therapeutically on the first type but is markedly effective on the second type.
This disease was classfied histologically into 3 types and the iodine metabolism was studied.
I. Type (colloidal type) no organic failure
II. Type (type with diffuse epithelial hyperplasia) marked organic failure
III. Type (type with degeneration)
a. Colliod stays considerably; no organic failure
b. Colloid reduced and the destructive follicles intensive; organic failure found
