“Clinical and Experimental Studies on the Decrease of Platelets Count Following Massive Blood Transfusion with Special Reference to the Nature of Platelet Clump Formation.”

Abstract

The nature of platelet clump formation following massive preserved blood transfusion was studied clinically and experimentally.
A heparin-like substance was increased in the plasma of recipients following massive preserved blood transfusion, which seemed to be a nature of the platelet clump formation.
The platelet clump formation is a transient reversible change, and not due to antigen-anti-body reaction.
It was presumed that the decrease of platelet count in recipient's peripheral blood was caused by sequestration of platelet mostly in liver, spleen, lung and bone marrow.