Analysis of the action of Illudin S: Effects of Illudin S on surface structures of L₉₂₉ fibroblasts

Abstract

The effects of Illudin S (a toadstool poison) on surface structures of L₉₂₉ mouse fibroblasts were studied by scanning electron microscopy. Illudin S in a concentration of 1 ng/ml strongly inhibited cell proliferation, but had no effect on surface structures of L cells through all the cell phases. These results indicate that the biological effects of Illudin S were not manifested by changes in the cytoskeletal system, the cell ability to attach to the substrate, of the surface structures of the cell. It is suggested that the cellular sensitive sites to Illudin S are inside the cell.