Pathohistological investigation on the mandible in autopsy cases of lymphatic reticulum cell sarcomatosis and lymphosarcomatosis.

Abstract

The mandibular bone marrow was examined histologically by using giant section slices in four autopsy cases of lymphatic reticulum cell sarcomatosis and in two cases of lymphosarcomatosis.
The metastases to the mandibular bone marrow of lymphatic reticulum cell sarcomatosis and lymphosarcomatosis were found in all cases examined. As to the extent of sarcoma cell infiltration in the mandibular bone marrow an extensive distribution such as from the condyle to incisor region was found in one case out of 6cases, a considerably extensive distribution such as from the condyle to premolar region in one case, and in the remaining four cases the distribution was different from case to case, often localized in either the condyle, ramus, or angle region.
Sarcoma cell proliferation was moderate in degree in one case and slight in the remaining five cases. The mode of sarcoma cell proliferation in the mandibular bone mar row was disseminated type in all cases, one of which simultaneously showing a massive type, and two. of which a diffuse type.Combined with disseminated type, three cases showed prominent aggregation of sarcoma cells in the perivascular area, and one case in the pericapillary and perinervous area, respectively.
Sarcoma cell infiltration in the fatty marrow was found in all cases and its distribution showed a disseminated type, and the metastatic foci were smaller and less than those in the hematopoietic marrow.
Sarcoma cell infiltration in the submucosa of the gingiva was found in two cases of lymphatic reticulum cell sarcomatosis and one of lymphatic sarcomatosis, showing no correlation with that in the mandibular bone marrow. No direct effect of such sarcoma cell infiltration in the mandibular bone marrow and the submucosa of the gingiva upon the teeth was found. No essential difference of sarcoma cell infiltration between lymphatic reticulum cell sarcoma and lymphosarcoma was found.