Immunohistochemical localization of ras p 21 in ameloblastoma

Abstract

The expression of ras p 21 and its histological localization on 13 ameloblastomas has been immunohistochemically studied using monoclonal antibody NCC-RAS-001 as the primary antibody. The ras p 21 was detected in 10/13 (76.9%) ameloblastomas; 3/5 (60.0%) were of the follicular and 7/8 (87.5%) of the plexiform type. In addition, ras p 21 was also detected in the cytoplasm of metaplastic squamous cells. The result suggested that ras p21 may be closely related to the proliferation and the development of tumor cells in ameloblastoma.