Dissolution assessment of manganese oxides in artificial sweat

―The determination of manganese with inductively coupled plasma mass spectrometry (ICP-MS) and inductively coupled plasma atomic emission spectrometry (ICP-AES)―

Abstract

We simulated sweat as artificial biological solution containing electrolytes and organic chemicals, and attempted to develop a method of dermal exposure assessment of metals compounds by analyzing the metal concentration in artificial biological solution. Manganese oxides were selected as test materials, and artificial sweat solution containing 18 different electrolytes and organic chemicals was used as matrix sample. There was little interference, such as spectral interference, between the chemicals used in the artificial sweat and manganese ion, and ICP-AES was able to determine the manganese ion in the artificial sweat without dilution. On the other hand, the influence of chloride from sodium chloride was observed in the ICP-MS analysis, ICP-MS required more than 5-fold dilution so that sodium chloride in artificial sweat was less than 300 μg/L. The results of this study are considered to provide important information for the evaluation of dermal exposure of metal compounds.