1967 Volume 9 Issue 3 Pages 113-120
Fucidic acid, of which fucidin is the sodium salt, was isolated from the fermentation broth of the fungus Fucidium coccineum (GODTFREDSEN et al.) [1]. Fucidin is a new antibiotic and mainly active against gram-positive microorganisms and Neisseria [2-5]. The chemical structure of fucidic acid is shown in Figure 1 [6], and related to that of cephalosporin P1. Consisting of the cyclopentanoperhydrophenanthrene ring system, it is important to determine if fucidin has the measurable effects as a steroid hormone. From such a point of view, there has been published only a report on the human being [7], though it is insufficient. In the present study, the steroid hormonal activities of fucidin have been investigated in the experimental animals.
