2011 Volume 14 Issue 2 Pages 76-83
Diabetes mellitus (DM) is one of the risk factors for periodontitis. Periodontal treatment improved glycemic control in diabetic human patients. Furthermore, it had been noticed that oxidant stress was increased in diabetic patients with periodontal diseases. The purpose of this study is to evaluate whether periodontal treatment effect for glycemic control and oxidant stress level in dogs with DM. Four dogs with DM maintained in our laboratory were used in this study. All diabetic dogs had chronic periodontitis, gingivitis and dental calculus. We evaluated glycated albumin (GA) and fasting blood glucose concentration (FBG) as glycemic control markers, and evaluated C-reactive protein (CRP) and tumor necrosis factor alpha (TNF-α) as inflammation markers, and evaluated d-ROMs (reactive oxygen metabolites) and BAP ( biological antioxidant potential) levels as oxidant stress markers before and after the periodontal treatment. Results indicated significant decrease in GA and CRP levels after periodontal treatment. Furthermore, a significant increase was observed in BAP level. However, there was no significant difference in FBG and TNF-α concentration and d-ROM level. These results suggested that periodontal treatment could improve glycemic control in dogs with DM.
