Abstract
This study aimed to evaluate the effect of dietary fat sources on lipid metabolism in different mouse strains. Three inbred mouse strains, C57BL/6J（B6）, BALB/cA（BALB）, and KK/Ta（KK）, were fed standard rodent chow（SC）and three high-fat diets with different dietary fats: safflower oil（HF-S）, lard （HF-L）, and purified palm oil powder（HF-P）for 6 weeks. Fatty acid compositions of HF-S, HF-L, and HF-P were monounsaturated fatty acids（MUFA）＞saturated fatty acids（SFA）, MUFA≒SFA, and MUFA＜SFA, respectively. Although energy intakes were significantly higher in the HF-P group than that of the other groups, body weight gains and fat weights were smaller compared to HF-S and HF-L groups in B6 and BALB. In KK mice, energy intakes, body weight gains, and fat weights in all high-fat diet groups were significantly higher than the SC group. Fasting blood glucose in B6 and BALB fed high-fat diets were also significantly elevated, particularly in HF-S and HF-L. HF-P groups of BALB and KK had significantly higher serum TG than that of the SC group. These results revealed that the lipid metabolisms in mice are clearly different depending on dietary fat sources and mouse strains.
