CHROMATOGRAPHY
Online ISSN : 1348-3315
Print ISSN : 1342-8284
ISSN-L : 1342-8284
Short communications
Evaluation of Volatility of Bendamustine Using Solid Phase Extraction-Type Extraction Device
Ikuo UETA Aya MIYAZAKIShinichiro YANORyosuke KIKUCHIKoki NAKAGAMIYoshihiro SAITOKeishi KAWATA
Author information
JOURNAL FREE ACCESS

2022 Volume 43 Issue 2 Pages 87-91

Details
Abstract

Bendamustine (BD), a volatile anti-cancer drug in Japan, was quantitatively evaluated using solid phase extraction (SPE)-type extraction device designed for the adsorption of gaseous semi-volatile organic compounds. First, the stability of BD was tested in various conditions, including solvent, temperature, and contact with oxygen. Then, the BD standard solution was spiked on filter paper, and the SPE-type extraction device was connected to the filter downstream. The filter and extraction device were then used to collect clean air. The actual volatility of BD was determined in high-performance liquid chromatography. Even after 24 h of air sampling at 7 L/min (10,080 L), the results demonstrated that BD evaporation was not confirmed. Furthermore, BD evaporation was not confirmed in a 7,000 L air sampling volume of heated air at 50°C. The volatility properties of n-alkanes of C26H54, C28H58, and C30H62 in these air sampling conditions were compared. The results show that BD is not volatile at room temperature.

Related papers from these authors
© 2022 The Society for Chromatographic Sciences
Previous article
feedback
Top