Nano- and Microbiodevices for High-Performance Separation of Biomolecules

Abstract

Nano- and microbiodevices were developed for the high-performance separation of DNA, RNA, protein, sugar chain, and other biomolecules. We describe numerous advantages of nano- and microbiodevices as the separation technologies, including HPLC and capillary electrophoretic separation of DNA, nanopillar devices for the ultra-fast separation of DNA and proteins, nanoball materials for the fast separation of wide range of DNA fragments, nanowire devices for ultra-fast separation of DNA, RNA, and proteins. Because of the high efficiency of nano- and microbiodevices for the separation of biomolecules in the clinical blood and urea samples, numerous types of nano- and microbiodevices were developed and applied to the diagnosis of diseases, including cancer, diabetes, hypertension, infectious diseases, and other noncommunicable diseases.