Journal of Pesticide Science
Online ISSN : 1349-0923
Print ISSN : 1348-589X
Review
Why Insecticides Are More Toxic to Insects than People: The Unique Toxicology of Insects
John E. CasidaGary B. Quistad
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2004 Volume 29 Issue 2 Pages 81-86

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Abstract

The unique toxicology of insects provides the safety mechanisms for the major insecticides. The selectivity of insecticidal nerve poisons is attributable to structural differences in binding subsites (acetylcholinesterase and nicotinic receptor) or receptor subunit interfaces (γ-aminobutyric acid receptor) or transmembrane regions (voltage-sensitive sodium channel) supplemented by metabolic activation and detoxification. Slow action limits the use of the remarkably selective insecticides acting at juvenile hormone and ecdysone receptors and inhibiting chitin biosynthesis. The δ-endotoxin of Bacillus thuringiensis induces midgut lysis and death in insects by a mechanism not applicable in mammals. Future pest management will rely on continuing advances in insect toxicology.

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© 2004 Pesticide Science Society of Japan
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