Induction of Heme Oxygenase-1 Inhibits Monocyte Chemoattractant Protein-1 mRNA Expression in U937 Cells

Tomoki Shokawa; Masao Yoshizumi; Hideya Yamamoto; Shinji Omura; Mamoru Toyofuku; Yoshito Shimizu; Michinori Imazu; Nobuoki Kohno

doi:10.1254/jphs.SC0040188

Short Communications

Induction of Heme Oxygenase-1 Inhibits Monocyte Chemoattractant Protein-1 mRNA Expression in U937 Cells

Tomoki Shokawa, Masao Yoshizumi, Hideya Yamamoto, Shinji Omura, Mamoru Toyofuku, Yoshito Shimizu, Michinori Imazu, Nobuoki Kohno

Author information

Keywords: heme oxygenase-1, oxidized low-density lipoprotein, monocyte chemoattractant protein-1

JOURNAL FREE ACCESS

2006 Volume 100 Issue 2 Pages 162-166

DOI https://doi.org/10.1254/jphs.SC0040188

View "Advance Publication" version (February 11, 2006).

Details

Abstract

Heme oxygenase-1 (HO-1) is a stress-inducible isoform of HO with potential cytoprotective effects. Monocyte activation/migration mediated by monocyte chemoattractant protein-1 (MCP-1) is one of the earliest and important events in the pathogenesis of atherosclerosis. We examined the effect of HO-1 on the production of lysophosphatidylcholine (Lyso-PC)-induced MCP-1 in the human promonocytic cell line U937. Increased HO-1 induction by hemin resulted in a significant decrease in the Lyso-PC-mediated induction of MCP-1 mRNA expression. SnPP (IX), the specific inhibitor of HO-1 enzymatic activity, prevented the hemin-mediated attenuation of MCP-1 mRNA expression. These results suggest that HO-1 may work as an anti-atherogenic agent through the attenuation of MCP-1 production.

Corresponding author

Register with J-STAGE for free!