Hypersensitivity to Hydroxyl Radicals in Rat Basilar Artery After Subarachnoid Hemorrhage

Tsuyoshi Nishihashi; Cristina C. Trandafir; Aimin Wang; Xu Ji; Yoshiharu Shimizu; Kazuyoshi Kurahashi

doi:10.1254/jphs.SC0050160

Short Communications

Hypersensitivity to Hydroxyl Radicals in Rat Basilar Artery After Subarachnoid Hemorrhage

Tsuyoshi Nishihashi, Cristina C. Trandafir, Aimin Wang, Xu Ji, Yoshiharu Shimizu, Kazuyoshi Kurahashi

Author information

Keywords: subarachnoid hemorrhage, hydroxyl radical, rat basilar artery

JOURNAL FREE ACCESS

2006 Volume 100 Issue 3 Pages 234-236

DOI https://doi.org/10.1254/jphs.SC0050160

View "Advance Publication" version (March 4, 2006).

Details

Abstract

Vasospasm after subarachnoid hemorrhage (SAH) is a serious complication and we have been investigating the relationship between vasoconstrictors and vasospasm after SAH. The present study was designed to investigate the vasocontractile responses to reactive oxygen species in isolated rat basilar arteries from the control and experimental SAH rats. Contractile responses to hydroxyl radicals in basilar arteries from SAH rats were 3 – 6-fold higher than those in control rats. The present results clearly indicate that hypersensitivity to hydroxyl radicals may contribute to the vasospasm after SAH.

Corresponding author

Register with J-STAGE for free!