A High-Sodium Diet in Streptozotocin-Induced Diabetic Rats Impairs Endothelium-Derived Hyperpolarizing Factor-Mediated Vasodilation

Yasutoshi Hirabara; Mina Araki; Mio Fukuda; Shiori Katafuchi; Kenji Honda; Ryo Saito; Yukio Takano

doi:10.1254/jphs.SC0070091

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A High-Sodium Diet in Streptozotocin-Induced Diabetic Rats Impairs Endothelium-Derived Hyperpolarizing Factor-Mediated Vasodilation

Yasutoshi Hirabara, Mina Araki, Mio Fukuda, Shiori Katafuchi, Kenji Honda, Ryo Saito, Yukio Takano

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Keywords: diabetes, mesenteric artery, endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation

JOURNAL FREE ACCESS

2007 Volume 104 Issue 4 Pages 402-405

DOI https://doi.org/10.1254/jphs.SC0070091

View "Advance Publication" version (August 4, 2007).

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Abstract

We examined endothelium-derived hyperpolarizing factor (EDHF)-mediated relaxation of mesenteric arteries in high-sodium loaded streptozotocin (STZ)-induced diabetic rats. The study shows that acetylcholine (ACh)-induced, EDHF-mediated relaxation is relatively maintained in STZ-induced diabetic rats, but after a high-sodium diet was given, the function was significantly impaired in STZ-induced diabetic rats.

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