Journal of Pharmacological Sciences
Short Communications
Involvement of GABAA Receptors in the Neuroprotective Effect of Theanine on Focal Cerebral Ischemia in Mice
Nobuaki EgashiraKazuhide HayakawaMegumi OsajimaKenichi MishimaKatsunori IwasakiRyozo OishiMichihiro Fujiwara
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Volume 105 (2007) Issue 2 Pages 211-214

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Abstract

We investigated the involvement of γ-aminobutyric acidA (GABAA) receptors in the neuroprotective effect of γ-glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice. Theanine (1 mg/kg) reduced the size of the cerebral infarct and alterations of NeuN, GFAP, and Iba 1 expression levels at 24 h after MCA occlusion. This neuroprotective effect of theanine was prevented by bicuculline (GABAA-receptor antagonist, 10 mg/kg) but not 3-mercaptopropionic acid (glutamate decarboxylase inhibitor). These results suggest that the neuroprotective effect of theanine is mediated, at least in part, by GABAA receptors.

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© The Japanese Pharmacological Society 2007
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