Journal of Pharmacological Sciences
Online ISSN : 1347-8648
Print ISSN : 1347-8613
ISSN-L : 1347-8613
Short Communications
Oseltamivir Enhances Hippocampal Network Synchronization
Atsushi UsamiTakuya SasakiNobuhiro SatohTakahiro AkibaSatoshi YokoshimaTohru FukuyamaKenzo YamatsuguMotomu KanaiMasakatsu ShibasakiNorio MatsukiYuji Ikegaya
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Supplementary material

2008 Volume 106 Issue 4 Pages 659-662

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Abstract

Oseltamivir, a widely used anti-influenza drug, inhibits virus neuraminidase. A mammalian homologue of this enzyme is expressed in the brain, yet the effect of oseltamivir on central neurons is largely unknown. Patch-clamp recordings ex vivo revealed that oseltamivir enhanced spike synchronization between hippocampal CA3 pyramidal cells. Time-lapse multineuron calcium imaging revealed that oseltamivir and its active metabolite evoked synchronized population bursts that recruited virtually all neurons in the network. This unique, so-far-unknown, event was attenuated by muscarinic receptor antagonist. Thus, oseltamivir is a useful tool for investigating a new aspect of neural circuit operation.

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© The Japanese Pharmacological Society 2008
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