Effects of Injectable Propofol Emulsion on Singlet Oxygen Released From Activated Human Neutrophils and That Chemically Generated

Chika Senda; Yoko Nishinaka; Toshiyuki Arai; Hajime Segawa; Hiroko Mori; Mitsuru Nonogawa; Nobuyuki Endo; Takashi Miyoshi; Kouhei Yamashita; Masataka Sasada

doi:10.1254/jphs.08040SC

Short Communications

Effects of Injectable Propofol Emulsion on Singlet Oxygen Released From Activated Human Neutrophils and That Chemically Generated

Chika Senda, Yoko Nishinaka, Toshiyuki Arai, Hajime Segawa, Hiroko Mori, Mitsuru Nonogawa, Nobuyuki Endo, Takashi Miyoshi ^†, Kouhei Yamashita ^†, Masataka Sasada

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Keywords: propofol emulsion, emulsifier, singlet oxygen

JOURNAL FREE ACCESS

2008 Volume 107 Issue 4 Pages 460-464

DOI https://doi.org/10.1254/jphs.08040SC

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Abstract

Effects of an injectable emulsion of propofol and its emulsifier on singlet oxygen (¹O₂) were examined. ¹O₂ released from activated human neutrophils was detected by chemiluminescence, and chemically generated ¹O₂ was detected by electron paramagnetic resonance (EPR). Both the propofol emulsion and the emulsifier suppressed ¹O₂ release from neutrophils. However, the emulsifier did not quench chemically generated ¹O₂, while the propofol emulsion quenched it. These results indicated that the emulsifier did not scavenge ¹O₂ released from neutrophils but inhibited ¹O₂ generation. The suppressive effects of propofol emulsion on ¹O₂ release from neutrophils consist of ¹O₂ scavenging and inhibition of ¹O₂ generation.

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