Journal of Pharmacological Sciences
Online ISSN : 1347-8648
Print ISSN : 1347-8613
ISSN-L : 1347-8613
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New Topics in Vasopressin Receptors and Approach to Novel Drugs:
Involvement of Vasopressin V1a and V1b Receptors in Nociceptive Responses and Morphine-Induced Effects
Kenji HondaYukio Takano
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2009 Volume 109 Issue 1 Pages 38-43


Arginine vasopressin (AVP) receptors have been classified into V1a, V1b, and V2 subtypes. Recent studies have demonstrated the involvement of AVP in anti-nociception and in morphine-induced anti-nociception. However, the roles of individual AVP-receptor subtypes have not been fully elucidated. Here, we have summarized the role of V1-receptor subtypes in behavioral responses to noxious stimuli and to morphine. In this review, we focus on studies using mice lacking the V1a receptor (V1a−/− mice) and the V1b receptor (V1b−/− mice).

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© The Japanese Pharmacological Society 2009
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