The New Salicylate Derivative UR-1505 Modulates the Th2/Humoral Response in a Dextran Sodium Sulphate Model of Colitis That Resembles Ulcerative Colitis

Elvira Bailón; Juan Román; Isabel Ramis; Pedro Michelena; Dolors Balsa; Manuel Merlos; Antonio Zarzuelo; Julio Gálvez; Mònica Comalada

doi:10.1254/jphs.08292SC

Short Communications

The New Salicylate Derivative UR-1505 Modulates the Th2/Humoral Response in a Dextran Sodium Sulphate Model of Colitis That Resembles Ulcerative Colitis

Elvira Bailón, Juan Román, Isabel Ramis, Pedro Michelena, Dolors Balsa, Manuel Merlos, Antonio Zarzuelo, Julio Gálvez, Mònica Comalada

Author information

Elvira Bailón
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Department of Pharmacology, School of Pharmacy, University of Granada, Spain
Juan Román
Pharmacology & Toxicology, Palau Pharma S.A, Spain
Isabel Ramis
Pharmacology & Toxicology, Palau Pharma S.A, Spain
Pedro Michelena
Pharmacology & Toxicology, Palau Pharma S.A, Spain
Dolors Balsa
Pharmacology & Toxicology, Palau Pharma S.A, Spain
Manuel Merlos
Pharmacology & Toxicology, Palau Pharma S.A, Spain
Antonio Zarzuelo
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Department of Pharmacology, School of Pharmacy, University of Granada, Spain
Julio Gálvez
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Department of Pharmacology, School of Pharmacy, University of Granada, Spain
Mònica Comalada
Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Department of Pharmacology, School of Pharmacy, University of Granada, Spain

Keywords: inflammatory bowel disease, B lymphocyte, Th2-cytokine

JOURNAL FREE ACCESS

2009 Volume 109 Issue 2 Pages 315-318

DOI https://doi.org/10.1254/jphs.08292SC

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Abstract

The aim of the present study was to evaluate the inmunomodulatory effects of UR-1505, a new salicylate derivative, on the T helper (Th)2 / humoral response produced during dextran sodium sulfate (DSS)-induced rat colitis. In the in vitro studies, UR-1505 (300 μM) inhibited both the production of interleukin (IL)-10 and IL-5 in concanavalin A (Con A)-activated splenocytes and the production of immunoglobulin (Ig) G and IgA by B-lymphocytes. However, in contrast to the in vitro results, the administration of UR-1505 (10 and 30 mg/kg per day) to rats with established DSS-colitis enhanced both IL-10 and IgA production, whereas it inhibited IgG production, thus ameliorating the intestinal inflammation.

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