Aldosterone-Sensitive Nucleus Tractus Solitarius Neurons Regulate Sensitivity of the Baroreceptor Reflex in High Sodium–Loaded Rats

Tomoharu Masuda; Yasutoshi Hirabara; Yusuke Nakamura; Akiko Chishaki; Mai Tsuruhisa; Masayuki Miyakawa; Kenji Honda; Ryo Saito; Hirotaka Sakamoto; Mitsuhiro Kawata; Yukio Takano

doi:10.1254/jphs.09362SC

Short Communications

Aldosterone-Sensitive Nucleus Tractus Solitarius Neurons Regulate Sensitivity of the Baroreceptor Reflex in High Sodium–Loaded Rats

Tomoharu Masuda, Yasutoshi Hirabara, Yusuke Nakamura, Akiko Chishaki, Mai Tsuruhisa, Masayuki Miyakawa, Kenji Honda, Ryo Saito, Hirotaka Sakamoto, Mitsuhiro Kawata, Yukio Takano

Author information

Tomoharu Masuda
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
Yasutoshi Hirabara
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
Yusuke Nakamura
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
Akiko Chishaki
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
Mai Tsuruhisa
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
Masayuki Miyakawa
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
Kenji Honda
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
Ryo Saito
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan
Hirotaka Sakamoto
Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, Japan
Mitsuhiro Kawata
Department of Anatomy and Neurobiology, Kyoto Prefectural University of Medicine, Japan
Yukio Takano
Department of Physiology and Pharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan

Keywords: aldosterone-sensitive nucleus tractus solitarius (NTS) neuron, arterial baroreceptor reflex, mineralocorticoid (MR) antagonist eplerenone

JOURNAL FREE ACCESS

2010 Volume 112 Issue 4 Pages 482-486

DOI https://doi.org/10.1254/jphs.09362SC

View "Advance Publication" version (March 20, 2010).

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Abstract

We examined the role of aldosterone-sensitive neurons in the nucleus tractus solitarius (NTS) in the arterial baroreceptor reflex (baroreflex) function. Baroreflex sensitivity was induced by phenylephrine in high sodium–loaded rats and was significantly reduced. This baroreflex sensitivity was reversed by microinjection of the mineralocorticoid receptor (MR) antagonist eplerenone into the NTS. 11β-Hydroxysteroid dehydrogenase type 2 neurons and MR were also identified in the NTS. These data suggest that the aldosterone-sensitive neurons in the NTS may have an important role in baroreflex function.

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