Interleukin-19 Is a Negative Regulator of Innate Immunity and Critical for Colonic Protection

Yasu-Taka Azuma; Yukiko Matsuo; Hidemitsu Nakajima; George D. Yancopoulos; David M. Valenzuela; Andrew J. Murphy; Margaret Karow; Tadayoshi Takeuchi

doi:10.1254/jphs.10R02CR

Critical Review

Interleukin-19 Is a Negative Regulator of Innate Immunity and Critical for Colonic Protection

Yasu-Taka Azuma, Yukiko Matsuo, Hidemitsu Nakajima, George D. Yancopoulos, David M. Valenzuela, Andrew J. Murphy, Margaret Karow, Tadayoshi Takeuchi

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Keywords: interleukin-19, inflammatory bowel disease (IBD), colonic inflammation, macrophages, cytokine

JOURNAL FREE ACCESS

2011 Volume 115 Issue 2 Pages 105-111

DOI https://doi.org/10.1254/jphs.10R02CR

View "Advance Publication" version (December 9, 2010).

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Abstract

The cytokine, interleukin (IL)-19, is a member of the IL-10 family that includes IL-20, IL-22, IL-24, and IL-26. Recent studies have shown that IL-19 is produced by keratinocytes, epithelial cells, macrophages, and B-cells. Little is known about the exact biological role of IL-19 in immunological regulation, although there is an increasing body of data demonstrating that IL-19 is associated with the development of Th2 responses and the pathogenesis of psoriasis. In this review, I shall attempt to discuss current knowledge about the role of IL-19 on macrophages and the potential role in inflammatory bowel disease.

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