Journal of Pharmacological Sciences
Online ISSN : 1347-8648
Print ISSN : 1347-8613
Critical Review
Neuropsychotoxic and Neuroprotective Potentials of Dextromethorphan and Its Analogs
Eun-Joo ShinJae-Hyung BachSung Youl LeeJeong Min KimJinhwa LeeJau-Shyong HongToshitaka NabeshimaHyoung-Chun Kim
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2011 Volume 116 Issue 2 Pages 137-148

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Abstract

Dextromethorphan (3-methoxy-17-methylmorphinan) has complex pharmacologic effects on the central nervous system. Although some of these effects are neuropsychotoxic, this review focuses on the neuroprotective effects of dextromethorphan and its analogs. Some of these analogs, particularly dimemorfan (3-methyl-17-methylmorphinan) and 3-hydroxymorphinan, have promising neuroprotective properties with negligible neuropsychotoxic effects. Their neuroprotective effects, the mechanisms underlying these effects, and their therapeutic potential for the treatment of diverse neurodegenerative disorders are discussed.

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© The Japanese Pharmacological Society 2011
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