Journal of Pharmacological Sciences
Online ISSN : 1347-8648
Print ISSN : 1347-8613
ISSN-L : 1347-8613
Short Communications
5-Hydroxytryptophan Attenuates Somatic Signs of Nicotine Withdrawal
Yu OhmuraEmily M. JutkiewiczMitsuhiro YoshiokaEdward F. Domino
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Keywords: addiction, smoking, tobacco
JOURNALS FREE ACCESS

2011 Volume 117 Issue 2 Pages 121-124

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Abstract

Abrupt nicotine cessation after chronic use disrupts monoaminergic systems and causes withdrawal signs/symptoms. In this study, the precursor of serotonin 5-hydroxytryptophan (5-HTP) relieved nicotine withdrawal signs. (−)-Nicotine bitartrate or equimolar sodium tartrate was infused into each rat via a s.c. osmotic minipump for 7 days. Somatic abstinence signs (teeth-chattering/chews and shakes, etc.) were counted one day after pump removal. Somatic signs were attenuated by the i.p. injection of 5-HTP, but not by NSD-1015, a centrally-acting L-aromatic amino acid decarboxylase inhibitor, indicating that 5-HTP mitigates somatic signs mainly through its conversion to 5-HT.

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© The Japanese Pharmacological Society 2011
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