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Journal of Pharmacological Sciences
Vol. 125 (2014) No. 1 p. 112-115

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http://doi.org/10.1254/jphs.14001SC

Short Communication

The functional role of brain G protein–coupled receptor 40 (GPR40) remains unclear. We investigated GPR40 signaling in depression-related behavior in mice via the forced swim test. A repeated but not a single intracerebroventricular administration of the GPR40 agonist, GW9508, reduced the duration of immobility behavior. Moreover, the levels of hippocampal non-esterified docosahexaenoic acid and arachidonic acid were decreased immediately after the forced swimming. These results suggested that brain GPR40 signaling may regulate depression-related behavior.

Copyright © 2014 The Japanese Pharmacological Society

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