Interferon Regulatory Factor 8 Expressed in Microglia Contributes to Tactile Allodynia Induced by Repeated Cold Stress in Rodents

Takanori Akagi; Yuta Matsumura; Masaya Yasui; Emiko Minami; Hidemasa Inoue; Takahiro Masuda; Hidetoshi Tozaki-Saitoh; Tomohiko Tamura; Kazue Mizumura; Makoto Tsuda; Hiroshi Kiyama; Kazuhide Inoue

doi:10.1254/jphs.14143SC

Short Communication

Interferon Regulatory Factor 8 Expressed in Microglia Contributes to Tactile Allodynia Induced by Repeated Cold Stress in Rodents

Takanori Akagi, Yuta Matsumura, Masaya Yasui, Emiko Minami, Hidemasa Inoue, Takahiro Masuda, Hidetoshi Tozaki-Saitoh, Tomohiko Tamura, Kazue Mizumura, Makoto Tsuda, Hiroshi Kiyama, Kazuhide Inoue

Author information

Takanori Akagi
Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
Yuta Matsumura
Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
Masaya Yasui
Department of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, Japan
Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Japan
Emiko Minami
Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
Hidemasa Inoue
Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
Takahiro Masuda
Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Japan
Hidetoshi Tozaki-Saitoh
Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
Tomohiko Tamura
Department of Immunology, Yokohama City University Graduate School of Medicine, Japan
Kazue Mizumura
Department of Physical Therapy, College of Life and Health Sciences, Chubu University, Japan
Makoto Tsuda
Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
Department of Life Innovation, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
Hiroshi Kiyama
Department of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine, Japan
Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Japan
Kazuhide Inoue
Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Japan
Core Research for Evolution Science and Technology, Japan Science and Technology Agency, Japan

Keywords: interferon regulatory factor-8, microglia, repeated cold stress

JOURNAL FREE ACCESS

2014 Volume 126 Issue 2 Pages 172-176

DOI https://doi.org/10.1254/jphs.14143SC

Browse “Advance online publication” version

Details

Abstract

We investigated the role of interferon regulatory factor 8 (IRF8) in a model of chronic pain in which repeated cold stress (RCS) exposure produces tactile allodynia. RCS exposure produced a decrease in paw withdrawal threshold (PWT) to mechanical stimulation. Spinal microglia of RCS-exposed mice were morphologically activated. Expression of IRF8 was significantly increased in the spinal cord of RCS-exposed mice and was localized in microglia. IRF8-knockout mice failed to show the RCS-induced decrease in PWT. Thus, RCS exposure activates spinal microglia and upregulation of IRF8 in these cells is involved in the development of tactile allodynia after RCS exposure.

Corresponding author

Register with J-STAGE for free!