Journal of Pharmacological Sciences
Online ISSN : 1347-8648
Print ISSN : 1347-8613
ISSN-L : 1347-8613
Short Communication
A Noninvasive Metabolic Syndrome Model Using an Extremely Small Minipig, the Microminipig
Takehiro YamaguchiTakanori YamazakiHiroaki KawaguchiMasashi TawaYasuhiro NakamuraMasayuki ShiotaMayuko Osada-OkaAkihide TanimotoTomio OkamuraKatsuyuki MiuraHiroshi IwaoMinoru YoshiyamaYasukatsu Izumi
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2014 Volume 126 Issue 2 Pages 168-171


Metabolic syndrome (MetS) induces serious complications; therefore, we developed a noninvasive MetS model using an extremely small minipig, the Microminipig. For 8 weeks, Microminipigs were administrated a high-fat and high-cholesterol diet (HFCD) for atherosclerosis and NG-nitro-l-arginine methyl ester (l-NAME) for inhibiting nitric oxide synthase. HFCD significantly increased serum low-density lipoprotein levels, l-NAME increased blood pressure and cardiac hypertrophy, and HFCD-induced aortal arteriosclerosis was accelerated by l-NAME administration. Endothelium-dependent relaxation of the coronary artery was remarkably decreased by l-NAME administration. This model may be useful for elucidating the mechanisms of MetS and developing new therapeutic medicines for its treatment.

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© 2014 The Japanese Pharmacological Society
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