Journal of Pharmacological Sciences
Online ISSN : 1347-8648
Print ISSN : 1347-8613
ISSN-L : 1347-8613
Short Communications
Changes in Blood Viscosity With Synthetic Protease Inhibitors
Masahito HitosugiMunehiro NiwaTomoyoshi TakahashiAkira KurosuHirohisa NiheiToshiaki NagaiShogo Tokudome
Author information

2003 Volume 91 Issue 4 Pages 334-336


We examined the effects on whole blood viscosity and coagulation time of various dosages of the synthetic low-molecular protease inhibitors gabexate mesilate and nafamostat mesilate with an oscillation-type viscometer. When either agent was added, blood viscosity decreased dose-dependently along a sigmoid-like curve. Furthermore, coagulation time was shorter with gabexate mesilate than with nafamostat mesilate owing to the differences of half-life in human blood. Thrombin generation, which results from the activation of coagulation factors, is inhibited by synthetic protease inhibitors and subsequently decreases blood viscosity dose-dependently.

Information related to the author
© The Japanese Pharmacological Society 2003
Previous article