Acute Metabolic Effects of Thiopental Anesthesia on Fed and Fasted Rats Chronically Treated With Bromocriptine

Antônio Ribeiro de Oliveira Jr.; Leida Maria Botion; Rachel Menezes Guerra; Rodrigo Bastos Fóscolo; Lucas José Campos Machado; Umeko Marubayashi; Adelina Martha dos Reis; Cândido Celso Coimbra

doi:10.1254/jphs.92.149

Short Communications

Acute Metabolic Effects of Thiopental Anesthesia on Fed and Fasted Rats Chronically Treated With Bromocriptine

Antônio Ribeiro de Oliveira Jr., Leida Maria Botion, Rachel Menezes Guerra, Rodrigo Bastos Fóscolo, Lucas José Campos Machado, Umeko Marubayashi, Adelina Martha dos Reis, Cândido Celso Coimbra

Author information

Antônio Ribeiro de Oliveira Jr.
Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais
Department of Internal Medicine, School of Medicine, Federal University of Minas Gerais
Leida Maria Botion
Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais
Rachel Menezes Guerra
Department of Internal Medicine, School of Medicine, Federal University of Minas Gerais
Rodrigo Bastos Fóscolo
Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais
Lucas José Campos Machado
Department of Internal Medicine, School of Medicine, Federal University of Minas Gerais
Umeko Marubayashi
Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais
Adelina Martha dos Reis
Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais
Cândido Celso Coimbra
Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais

Keywords: thiopental, bromocriptine, insulin

JOURNAL FREE ACCESS

2003 Volume 92 Issue 2 Pages 149-152

DOI https://doi.org/10.1254/jphs.92.149

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Abstract

We investigated the acute effects of thiopental anesthesia (4 mg/100 g, i.v.) on plasma glucose, insulin, triacylglycerol, and prolactin levels in rats treated with bromocriptine (BR) (0.4 mg/100 g body wt, i.p., for two weeks). Thiopental anesthesia induced a rapid increase in plasma insulin that was more pronounced in the animals treated with BR (116%, P<0.05). Thiopental anesthesia also produced a 55% decreased in plasma prolactin levels (P<0.01) in control fed rats, and a 22% reduction in plasma triacylglycerol (P<0.05) in both controls and BR-treated rats. We conclude that BR may constitute and additional sympatholytic factor in animals submitted to thiopental anesthesia.

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