Journal of Pharmacological Sciences
Online ISSN : 1347-8648
Print ISSN : 1347-8613
ISSN-L : 1347-8613
Short Communications
Red Ginseng Inhibits Exercise-Induced Increase in 5-Hydroxytryptamine Synthesis and Tryptophan Hydroxylase Expression in Dorsal Raphe of Rats
Yeong-Ki MinSeok-Hee ChungJong-Soo LeeSung-Soo KimHyun-Dae ShinBaek-Vin LimMin-Chul ShinMi-Hyeon JangEe-Hwa KimChang-Ju Kim
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2003 Volume 93 Issue 2 Pages 218-221

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Abstract

Red ginseng has been used as an ergogenic aid for endurance exercise. In this study, the effect of aqueous extract of Red ginseng on the endurance in treadmill exercise and 5-hydroxytryptamine (serotonin) synthesis and tryptophan hydroxylase expression in the dorsal raphe of rats were studied. Rats receiving Red ginseng showed increased time to exhaustion for treadmill running, and Red ginseng treatment inhibited exercise-induced increases in 5-hydroxytryptamine synthesis and tryptophan hydroxylase expression in the dorsal raphe. These results suggest that the suppressive effect of Red ginseng on serotonin level during exercise is a possible ergogenic mechanism of Red ginseng.

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© The Japanese Pharmacological Society 2003
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