Journal of Pharmacological Sciences
Online ISSN : 1347-8648
Print ISSN : 1347-8613
ISSN-L : 1347-8613
Short Communications
Cyclooxygenase Inhibitors Attenuate Augmented Glutamate Release in Organum Vasculosum Laminae Terminalis and Fever Induced by Staphylococcal Enterotoxin A
Wu-Tein HuangJhi-Joung WangMao-Tsun Lin
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Keywords: glutamate, fever, diclofenac

2004 Volume 94 Issue 2 Pages 192-196


Both the hyperthermia and augmented glutamate release in the organum vasculosum laminae terminalis (OVLT) after an intravenous dose (30 ng/kg) of staphylococcal enterotoxin A (SEA) were significantly reduced by pretreatment with intravenous administration of cyclooxygenase inhibitors such as aspirin (1 – 10 mg/kg), sodium salicylate (1 – 10 mg/kg), or diclofenac (10 mg/kg). Intra-OVLT administration of 50 – 200 μg in 1.0 μl of either aspirin or sodium salicylate 60 min before or 120 min after an intra-OVLT dose (50 μg in 1.0 μl) of glutamate also significantly suppressed the glutamate-induced hyperthermia. These findings suggest that inhibition of cyclooxygenase receptor mechanisms suppresses SEA fever by inhibition of glutamate release in the OVLT of rabbit brain.

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© The Japanese Pharmacological Society 2004
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