Journal of Pharmacological Sciences
Online ISSN : 1347-8648
Print ISSN : 1347-8613
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The R(−)-Enantiomer of Efonidipine Blocks T-type but Not L-type Calcium Current in Guinea Pig Ventricular Myocardium
Hikaru TanakaChisa KomikadoHideaki ShimadaKentaro TakedaIyuki NamekataToru KawanishiKoki Shigenobu
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2004 Volume 96 Issue 4 Pages 499-501

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Abstract

In guinea pig ventricular cardiomyocytes, the R(−)-enantiomer of efonidipine concentration-dependently blocked T-type Ca2+ current with 85% inhibition at 1 μM. In contrast, R(−)-efonidipine (1 μM) had no effect on the L-type Ca2+ current and Ca2+ transient in cardiomyocytes and contractile force in papillary muscles. Thus, R(−)-efonidipine is a highly selective blocker of the T-type Ca2+ current in native myocardia.

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© The Japanese Pharmacological Society 2004
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