The R(−)-Enantiomer of Efonidipine Blocks T-type but Not L-type Calcium Current in Guinea Pig Ventricular Myocardium

Hikaru Tanaka; Chisa Komikado; Hideaki Shimada; Kentaro Takeda; Iyuki Namekata; Toru Kawanishi; Koki Shigenobu

doi:10.1254/jphs.RCJ04001X

Rapid Communication

The R(−)-Enantiomer of Efonidipine Blocks T-type but Not L-type Calcium Current in Guinea Pig Ventricular Myocardium

Hikaru Tanaka, Chisa Komikado, Hideaki Shimada, Kentaro Takeda, Iyuki Namekata, Toru Kawanishi, Koki Shigenobu

Author information

Keywords: R(−)-efonidipine, T-type Ca²⁺ channel, cardiomyocyte

JOURNAL FREE ACCESS

2004 Volume 96 Issue 4 Pages 499-501

DOI https://doi.org/10.1254/jphs.RCJ04001X

View "Advance Publication" version (December 15, 2004).

Details

Abstract

In guinea pig ventricular cardiomyocytes, the R(−)-enantiomer of efonidipine concentration-dependently blocked T-type Ca²⁺ current with 85% inhibition at 1 μM. In contrast, R(−)-efonidipine (1 μM) had no effect on the L-type Ca²⁺ current and Ca²⁺ transient in cardiomyocytes and contractile force in papillary muscles. Thus, R(−)-efonidipine is a highly selective blocker of the T-type Ca²⁺ current in native myocardia.

Corresponding author

Register with J-STAGE for free!