The Protective Effect of Radicicol Against Renal Ischemia–Reperfusion Injury in Mice

Hiroko Sonoda; Worapat Prachasilchai; Hiroaki Kondo; Naoko Yokota-Ikeda; Sayaka Oshikawa; Katsuaki Ito; Masahiro Ikeda

doi:10.1254/jphs.09259SC

This article has now been updated. Please use the final version.

The Protective Effect of Radicicol Against Renal Ischemia–Reperfusion Injury in Mice

Hiroko Sonoda, Worapat Prachasilchai, Hiroaki Kondo, Naoko Yokota-Ikeda, Sayaka Oshikawa, Katsuaki Ito, Masahiro Ikeda

Author information

Keywords: radicicol, renal ischemia–reperfusion injury, heat shock protein 70 kDa (HSP70)

JOURNAL FREE ACCESS Advance online publication

Article ID: 09259SC

DOI https://doi.org/10.1254/jphs.09259SC

The final version of this article is now available: Vol. 112 (2010) , No. 2 p.242

Details

Abstract

Overexpression of heat shock protein 70 kDa (HSP70) is known to confer cellular protection against ischemia–reperfusion (I/R) injury. Radicicol, a HSP90 inhibitor, has been reported to induce the expression of HSP70 protein. Here we studied whether radicicol attenuated renal I/R injury in vivo. Treatment of mice with radicicol ameliorated renal I/R injury and increased renal HSP70 mRNA and protein. Administration of radicicol with quercetin, an inhibitor of HSP70 induction, eliminated the renoprotective effect of radicicol. Our results suggest that the up-regulation of renal HSP70 protein by radicicol leads to a novel drug therapy against renal I/R injury.

Corresponding author

Register with J-STAGE for free!