Abstract
We have already reported on the action of drugs such as acetylcholine, epinephrine, reserpine, cardiac glycosides, antiarrhythmic agents, veratrine and chelating agents on the intracellular action potentials recorded from the ventricular muscle, sinoatrial node and the non-pacemaker atrial fibers of the isolated rabbit heart using the ultramicroelectrode method (1-3).
The present experiments were undertaken to determine the influences of anticholinesterases on the membrane potentials of the isolated rabbit atrial muscle exhibiting spontaneous beating. Observations on the antagonisms between the action of anticholinesterases and of cholinesterase reactivators on the membrane potentials were also designed.
