Abstract
The structure-activity relationship of various chemical compounds, which resembled to morphine in their structures and were synthesized by Sugimoto et al. (1), has been reported. Among those compounds a racemic 6-hydroxy-4a, 10-trimethylene-1, 2, 3, 4, 4a, 9, 10, 10a-octahydrophenanthridine hydrochloride (DH-7), which have a nitrogen atom at 9-position of the morphinan ring, showed almost the same strong analgesic activities as morphine hydrochloride in a series of screening test.
Further studies of the analgesic activity of DH-7 and the comparative pharmacological studies of the drug with morphine hydrochloride and levorphanol tartrate are described in this report. DH-7 has a chemical structure, shown in the following structural formula.
