Abstract
The depression of the spontaneous movement of mice by xylopinine, 2, 3, 10, 11-tetramethoxy-5, 6-13a-tetrahydro-8-dibenzo(a-g)quinolizinc, has been reported by Nakanishi (1). In the unanesthetized rabbit, the intravenous injection of xylopinine produced high voltage slow waves and increased spindle waves in EEG. The threshold voltage for eliciting the reticular arousal response by stimulation of the ascending reticular formation was also elevated.
Recently, Hsu and Kin (2) have studied the pharmacological effects of tetrahydropalmatine and its analogues. They showed that tetrahydropalmatine exerted sedativetranquilizing effects in mice.
The present experiments were designed to study sedative-tranquilizing effects of xylopinine in mice.
