Abstract
It has been shown that tetrabenazine depletes the brain serotonin and noradrenaline (1, 2). The action of tetrabenazine resembles that of reserpine but differs from it in certain important respects. Tetrabenazine depletes the brain noradrenaline more than brain serotonin, having little effect peripherally (2). Although Mathis et al. (3) and Bente (4) reported on the electroencephalographic studies of tetrabenazine in man, more precise electrophysiological analysis on the site of action of tetrabenazine remains to be investigated.
The present investigation was designed to determine the site and mode of action of tetrabenazine on the central nervous system by means of the electrophysiological methods.
