ANABOLIC AND OTHER HORMONAL ACTIVITIES OF 2α, 17α-DIMETHYL-19-NORTESTOSTERONE AND ITS DERIVATIVES

Abstract

Since the first finding by Kochakian and Murlin (1), many investigators have coincided in revealing that testosterone produced a positive balance of nitrogen, calcium, potassium and phosphorus in the experimental animals. Hershberger et al. (2) have shown that 19-nortestosterone and its 17-substituted derivative, norethandrolone, exhibit a high myotrophic activity on the levator ani muscle with a considerable high anabolicandrogenic ratio. However, the clinical studies (3) have shown that ethyl derivative of 19-nortestosterone still retains the inherent side effects of anabolic steroids such as androgenic or progestational activities. The present report concerns mainly with anabolic and other hormonal activities of 2α, 17α-dimethyl-19-nortestosterone and its derivatives in the experimental animals.