Abstract
In this laboratory, Misu (1) have studied the effects of the adrenolytics on the atrial transmembrane potentials of the isolated rabbit's heart, and have shown that the adrenolytics decrease the rate and amplitude and prolong the total duration of the potentials until the complete disappearance of the potential, and that the abolished potential change is not restarted by the washing-out of the preparation but is restarted by the administration of adrenaline or noradrenaline.
Theses results prompted the current experiments, in which the effects of the intravenous injection of the adrenolytics such as dibenamine, chlorpromazine and yohimbine on the catecholamine content of the various tissues were studied in rabbits in order to elucidate the mode of action of the adrenolytics.
