Abstract
The sympathetic nature of the hypogastric innervation of the ductus deferens of guinea-pig has been concluded by Hukovic (1) from the results that the contractile response of the isolated ductus deferens to stimulation of the hypogastric nerve is enhanced by the addition of noradrenaline and is abolished by the previous reserpinization of the animal. In the same line Boura et al. (2) and Bentley (3) have shown that the response is abolished by the addition of reserpine, guanethidine and bretylium. The enhancement of the response by the addition of carbamyl-choline has been shown by Bentley. Boyd et al. (4) and Burn et al. (5) have demonstrated the enhancement of the response by the addition of eserine and various adrenolytics. The potentiating effect of the adrenolytics has been explained by the anticholinesterase activity of the drugs. The transmission failure of the sympathetic nerve impulse in the preparation by hemicholinium has been shown by Chang and Rand (6) and Bentley (3). The inhibition of the contractile response by the ganglionic blocking agents has been shown by Sjöstrand (7) and Bentley (3). Sjöstrand (8) has proved that the chronic denervation of the ductus deferens does not affect the level of noradrenaline in the tissue. He has further indicated that the cholinergic mechanism of impulse transmission in the preparation is responsible for the release of the endogenous noradrenaline.
The assumption that the peripheral cholinergic mechanism is involved in the sympathetic innervation of the ductus deferens of guinea-pig facilitated the current studies.
