CENTRAL DEPRESSANT EFFECTS OF SOME IMIDAZOLIDINONE DERIVATIVES

Abstract

In the course of our investigation on a series of synthetic imidazolidinone derivatives we have found that some of these substances had central nervous system depressant properties in experimental animals. Among these were 4, 5-bis-alkyloxy or -alkenyloxy derivatives of 2-imidazolidinone with the following chemical structures:
These compounds, for the sake of convenience, will be referred to by their code numbers SRC-906 and SRC-916 respectively.
SRC-916 is a new substance which has never been disclosed in any printed articles. SRC-906 and -916 are colorless, white needle, stable crystalline which are insoluble in water, soluble in methanol, chloroform and benzene. The melting point of SRC-906 is 104°C-105°C and of SRC-916 is 68°C-70°C.
The purpose of this paper is to evaluate the effect of SRC-906 and SRC-916 as compared with that of Ethinamate on the following activities: 1) acute toxicity and hypnotic activity in mice, 2) anticonvulsant activity in mice, 3) potentiation of barbiturate hypnosis in mice, 4) sedative and hypnotic activity in cats and 5) effect on electroencephalogram of cats.