Abstract
Clinically interesting substances, such as necrotizing factor in rheumatoid arthritis, skin sensitizing antibody and complement in allergic diseases were easily inactivated by heating or even keeping them in room temperature. And there are many reports that heavy metal ions inhibit the activity of physico-chemically labile substances such as some kind of enzyme. On the other hand, gold compound was proved to have an antirheumatic effect and probably a therapeutic effect in some allergic disease. Colloidal platinum and palladium were tried to apply in treatment of rheumatism in Japan.
In this experiment, inhibitory effects of metal compounds including gold and platinum on the necrotizing factor, skin sensitizing antibody and complement were studied.
