Abstract
Referring to the relationship between the pharmacological actions of nicotine and the biogenic active substances, a certain biogenic amine released by nicotine has been suggested to participate in some pharmacological actions of nicotine (1). Especially the release of epinephrine from the adrenal medulla by nicotine has been proven (2-7). The significance of the actions of biogenic amines has been recognized to elucidate the mechanism of the drug actions, since much more reliable methods of assays for identification were developed (8-13).
The present experiment was designed to observe the relationship between the contents of the biogenic catechols in the several tissues of rats and the behavial changes of three patterns of nicotine-induced convulsions.
