Abstract
It has been reported that spleen strips contract with an addition of adrenaline (13), noradrenaline (3), acetylcholine (1-3), histamine (1-2) or 5-hydroxytryptamine (2) to the bath medium. The adrenaline-induced contraction of the spleen strips can be blocked by alpha-adrenergic blocking agents (1-4). According to Bickerton (4), isoproterenol, which stimulates beta-adrenergic receptors, also contracts the spleen strips and the isoproterenol-induced contraction is specifically blocked by a beta-adrenergic blocking agent, dichloroisoproterenol (5).
The present paper describes that pronethalol, one of the beta-adrenergic blocking agents originally reported by Black and Stephenson (6), inhibits the contraction of spleen strips produced by adrenaline, acetylcholine or isoproterenol, in different species of animals.
