Abstract
Strom and Coffman (1) found that aspirin produced a significant reduction in peripheral blood flow responses to i.v. epinephrine and nor-epinephrine in human beings. Hashimoto et al. (2) studied the effect of sodium salicylate on reflex vascular responses to dimethylamino prophy-tetrahydro-azaazepino phenothiazine (RPP201), andromedotoxin, veratridine, bradykinin and kallikrein injected in the femoral or renal artery of the isolated hindlimb or kidney preparation perfused by cross-circulation. Sodium salicylate abolished completely the pressor response to RPP201, andromedotoxin, veratridine, bradykinin or kallikrein. The depressor response to the last two agents was, however, unaffected. Anticholinergic, antiadrenergic, antihistaminic, antiserotonin and neuromuscular or ganglion-blocking agents did not influence the reflex vascular response. Since salicylates are used as anti-inflamatory and anti-rheumatic agents, an action on the blood vessels may be of significance in the mechanism of this effect. Hence it was thought of interest to study the effect of salicylates on responses to certain other pressor and depressor agents. The results obtained are reported in this communication. A preliminary report of the work has been presented [Ahmad and Dhawan (3)].
